Endocrine Abstracts

Objective: To determine the relationship between metabolic syndrome (MS) and cognitive decline in people over 60 years age.Methods: The age of the participants were between 60 and 89 years old (71.71±6.58). According to NCEP ATP III criteria 93 had MS and 47 had not. Cognitive performance was determined with the use of standardized mini mental test and the mini mental scores (MMS) of the two groups were compared. Apart from the MS we investigated th...

Introduction: Although the syndrome of inappropriate antidiuretic hormone (SIADH) has connection with various malignant tumors, the pituitary metastasis of malignant tumors are generally associated with diabetes insipidus.Case report: A 59 years old male patient presented to emergency service with frequent syncope attacks, nausea, loss of appetite and fatigue that began 2 weeks prior to admission. Marked obtundation was found on physical examination. The...

Introduction: The results of publications investigating the relationship between low maternal serum 25-hydroxyvitamin D (25OHD) level and gestational diabetes mellitus (GDM) are controversial and none of these publications have investigated this relationship according to the severity of 25OHD deficiency. Therefore, this study was conducted to assess the relationship between low maternal serum 25OHD and GDM according to the severity of 25OHD deficiency.Me...

IntroductionSome, cases of autoimmune diseases were previously reported after surgical remission of CD. In most cases, autoimmune diseases have generally been reported in younger females. However, some cases of Hashimoto’s thyroiditis, multiple sclerosis, vitiligo, and sarcoidosis in male patients, after the restoration of hypercortisolemia have been reported as well. Nevertheless, an immediate occurrence of severe erosive rheumatoid arthritis (RA) ...

IntroductionMulticentric Castleman disease (MCD) is characterized by highly vascularized multiple lymph node enlargements throughout the body. MCD is generally treated with systemic cytotoxic chemotherapy, with its attendant risk for toxicity. Studies suggest the presence of growth hormone receptors (GHR) in lymphatic tissues of patients with Castleman disease. However, the effect of somatostatin analogs for the treatment of MCD is not reported so far. H...

IntroductionThe diagnosis of insulinomas is made biochemically. However, proper localization of insulinomas is essential before surgery. Non-invasive methods including magnetic resonance imaging (MRI), computed tomography, ultrasonography, glucagon-like peptide-1 receptor PET/CT, 68Ga-DOTATATE PET/CT, and invasive methods such as endoscopic ultrasonography (EUS) and selective arterial calcium stimulation test are used for preoperative localization. Howev...

IntroductıonRecent studies suggest temozolomide as an effective treatment modality in invasive pituitary adenomas that did not respond to conventional treatments. In this case series, we present three cases of invasive pituitary adenomas that did not respond to conventional medical treatments and radiotherapy and were subsequently treated with temozolomide.CasesThe first patient had an invasive prolactin...

Background: Von Hippel-Lindau disease (VHL) is an autosomal dominant disease, characterized by haemangioblastomas of the retina and CNS, renal cell carcinomas (RCC) and renal cysts, pheochromocytomas, pancreatic neuroendocrine tumors and cysts, and endolymphatic sac tumors. VHL is associated with a germline mutation of the VHL tumor suppressor gene on the short arm of chromosome 3. The type-1 disease is caused by mutations, leading to severe disruption of protein acti...

Objectives: The frequency of Cushing’s disease (CD), ACTH independent Cushing’s syndrome (CS) and autonomous cortisol secretion (ACS) in patients with obesity is not well known and the results of the studies are heterogeneous. Therefore, in the present study, we aimed to assess the frequency of CD, CS, and ACS among patients with obesity.Methods: In this study, 813 consecutive patients [683 female, mean age 46.47±14.23-year-old, mean BMI 3...

Objective: Despite the high sensitivity of TRAb measured by modern assay methods, some patients with Graves’ disease (GD) may still have normal TRAb levels. Therefore, the purpose of this study was to determine the clinical utility of TRAb measured by a third generation assay method, and to determine it’s relationship with clinical and laboratory parameters in Turkish patients with GD.Methods: In this study, 328 consecutive treatment-naive pati...